GDFT hemodynamic stability in parturient women under spinal epidural

Patient Population

LiDCO Monitor

Trial Design
100 term parturient women scheduled for elective cesarean section randomly allocated to GDFT or a control group.

Outcome Impact
The incidence of hypotension and mean phenylephrine dose administered prior to delivery were significantly higher in the control group than in the GDFT group (P < 0.01).

To investigate whether goal-directed fluid therapy (GDFT) with the LiDCOrapid system can reduce the incidence of maternal hypotension and improve neonatal outcome.

100 term parturient women with ASA physical status 1 scheduled for elective Cesarean section at Xuan Wu Hospital of Capital Medical University, Beijing were randomly allocated to control or GDFT group.

Maternal outcome in the control group showed a significantly higher incidence of hypotension prior t delivery in the control group than the GDFT group (62% vs 20%, P < 0.01). Higher does of phenylephrine were administered before delivery (P < 0.01) in the control group.

LiDCOrapid-guided GDFT may provide benefit to healthy parturient women and their newborns.

Xiao W, Duan Q, Zhao L, Chi X et al. Goal-directed fluid therapy may improve hemodynamic stability in parturient women under combined spinal epidural anesthesia for cesarean section and newborn well-being. J. Obstet. Gynaecol. Res. 2015; 41(10):1547–1555

“LiDCOrapid-guided GDFT can reduce the incidence of maternal hypotension and vasopressor requirement during operation, with a subsequent decrease in the incidence of neonatal adverse events.”

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