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Lithium Dilution

The LiDCO System - derivation of cardiac output from the lithium indicator dilution curve

Key Supporting Science & Studies

L1.1 Linton RAF, Band DM & Haire KM. (1993) A new method of measuring cardiac output in man using lithium dilution. British Journal of Anaesthesia; 71: 262-266

L1.2. Band D, Linton R. (1994) A New way of Measuring Cardiac Output. The Physiological Society Magazine 17:21

L1.3. Linton R, Band D, O'Brien T, Jonas MM & Leach R. (1997) Lithium dilution cardiac output measurement: A comparison with thermodilution. Critical Care Medicine; 25: 1796-1800

L1.4. Kurita T, Morita K, Kato S, Kikura M, Horie M, Ikeda K. (1997) Comparison of the accuracy of the lithium dilution technique with the thermodilution technique for measurement of cardiac output. British Journal of Anaesthesia; 79: 770-775

L1.5. Linton RAF, Band DM, O'Brien TK, Linton NWF & Jonas MM. (1998) Lithium dilution cardiac output measurement - a brief review. In: State-of-the-Art Technology in Anesthesia and Intensive Care , pp 61-66. Edited by: Ikeda K, Doi M & Kazama T; pub. Elsevier Science B.V., Amsterdam

L1.6. Jonas MM, Kelly FE Linton RAF, Band DM, O'Brien TK, Linton NWF. (1999) A comparison of lithium dilution cardiac output measurements made using central and antecubital venous injection of lithium chloride. Journal of Clinical Monitoring & Computing, 15: 525-528

L1.7. Jonas, Linton, O'Brien, Band, Linton, Kelly, Burden, Chevalier, Thompson, Birch and Powell. (2001) The pharmacokinetics of intravenous lithium chloride in patients and normal volunteers. Journal of Trace and Microprobe Techniques. 19: 313-320

L1.8. Garcia-Rodriguez C, Pittman J, Cassell CH, Sum-Ping J, El-Moalem H, Young C, Mark JB. (2002) Lithium dilution cardiac output measurement: A Clinical assessment of central venous and peripheral venous indicator injection. Crit Care Med Vol. 30, No. 10 p2199-2204

L1.9. Kurita T, Morita K, Kawasaki H, Fujii K, Kazama T, Sato S. (2002) Lithium Dilution Cardiac Output Measurement in Oleic Acid-Induced Pulmonary Edema. Journal of Cardiothoracic and Vascular Anesthesia, Vol 16, No 3 (June): pp 334-337

L1.10. Mason D, O’Grady M, Woods P, McDonell W. (2002) Effect of background serum lithium concentrations on the accuracy of lithium dilution cardiac output determination in dogs. American Journal of Veterinary Research; 63 : 1048 – 1052

L1.11. Pittman J, Bar Yosef S, SumPing J, Sherwood M, Mark J (2005) Continuous cardiac output monitoring with pulse contour analysis: A comparison with lithium indicator dilution cardiac output measurement. Crit Care Med. 33 (9) 2015-2021

L1.12. Cecconi M, Dawson D, Grounds R, Rhodes A. (2008) Lithium dilution cardiac output measurement in the critically ill patient: determination of precision of the technique. Intensive Care Medicine; 35 : 498 – 504

L1.13. Kemps H, Thijssen E, Schep G, Sleutjes B,De Vries W, Hoogeveen A, Wijn P, Doevendans P. (2008) Evaluation of two methods for continuous cardiac output assessment during exercise in chronic heart failure patients. J Appl Physiol 105: 1822-1829

L1.14. Hannegard-Hamrin T, Odeberg-Wenerman S (2010) Lithium indicator technique for cardiac output in children: reproducibility of the calibration factor. Proceedings of the 2010 Annual Meeting of the ESICM

Further Presented & Published LiDCO System Studies

L2.1. Linton RAF, Linton NWF & Band DM. (1995) A new method of analysing indicator dilution curves. Cardiovascular Research; 30: 930-938

L2.2. Morita K, Kurita T, Kikura M, Ikeda K. (1995) Accuracy of the Lithium Dilution Cardiac Output Measurement. Meeting of the European Society for Computing and Technology in Anaesthesia and Intensive Care, Palermo

L2.3. Linton R, Band D. (1995) Cardiac Output Measured by Indicator Dilution Using Lithium Chloride. Meeting of the Japanese Society for Anaesthesia, Hamamatsu

L2.4. Band DM, Linton RAF, O'Brien TK, Jonas M & Linton NWF. (1997) The shape of indicator dilution curves used for cardiac output measurement in man. Journal of Physiology; 498: 225-229

L2.5. Linton R, Turtle M, Band D, O'Brien T & Jonas M. (1998) In vitro evaluation of a new lithium dilution method of measuring cardiac output and shunt fraction in patients undergoing venovenous extracorporeal membrane oxygenation. Critical Care Medicine; 26: 174-177

L2.6. Linton RAF, Taylor PM, Linton NWF, Flach EJ, O'Brien TK, Band DM. (1999) Cardiac output measurement in an anaesthetised giraffe. The Veterinary Record, October 23;145(17):498-9

L2.7. Mappes A, Wiersich S, Siniawski H, Lindert J, Kuppe H. (1999) Comparison of three different technologies of measuring cardiac output (CO) in patients undergoing open heart surgery. Meeting of the American Society of Anesthesiology, Dallas October

L2.8. Peruzzi W. (2000) Ion selective electrodes and critical care monitoring. American Society of Critical Care Anesthesiologists Interchange. 12: 3&7

L2.9. Mappes A, Wiersich S, Koster A, Lindert J, Kuppe H. (1999) Lithium dilution cardiac output measurement in patients undergoing coronary artery bypass grafting. Meeting of the European Society of Intensive Care Medicine, Berlin, October

L2.10. Linton RAF, Turtle M, Band DM, O'Brien TK, Jonas MM & Linton NWF. (1999) A new technique for measuring cardiac output and shunt fraction during venovenous extracorporeal membrane oxygenation. Perfusion; 14: 43-47

L2.11. Garcia-Rodriguez C, Cassell C, Young C, Sum Ping J. Mark J. (2000) Cardiac output measurement without pulmonary artery or central venous catheterization: A clinical assessment of the lithium dilution method. American Society of Anesthesiology, San Francisco October

L2.12. Linton RAF, Linton NWF, Kelly F. (2000) How accurate is clinical assessment of cardiac output in the early postoperative period following cardiac surgery? American Society of Anesthesiology, San Francisco CA October

L2.13. Linton RA, Jonas MM, Tibby SM, Murdoch IA, O'Brien TK, Linton NW, Band DM. (2000) Cardiac output measured by lithium dilution and transpulmonary thermodilution in patients in a paediatric intensive care unit. Intensive Care Med. Oct; 26(10): 1507-11. [The use of the LiDCO lithium dilution measurement of cardiac output is not licensed for use in patients of less than 40 kgs / 88Ilbs in weight]

L2.14. Linton RA, Young LE, Marlin DJ, Blissett KJ, Brearley JC, Jonas MM, O'Brien TK, Linton NW, Band DM Jones RS. (2000) Cardiac output measured by lithium dilution, thermodilution and transesophageal Doppler echocardiography in anesthetized horses. American Journal of Veterinary Research Jul; 61(7): 731-7

L2.15. Linton RAF. (2000) Cardiac output measured by lithium dilution. EACTA meeting, Aarhus Denmark June

L2.16. Mappes A, Gruendel M, Lindert J, Wiersich S, Kuppe H. (2000) Hemodynamic monitoring in cardiac surgery: changes in mean arterial pressure do not correlate with the associated changes in cardiac output. EACTA meeting, Aarhus Denmark June

L2.17. Mappes A, Lindert J, Wiersich S, Gruendel M, Kuppe, H. (2000) Hemodynamic monitoring during cardiac surgery: the new LIDCO method. Cardiothoracic Technologies and Techniques meeting, Bal Harbour Florida, January

L2.18. Mason DJ, O'Grady M, Woods JP, McDonell W. (2001) Assessment of lithium dilution cardiac output as a technique for measurement of cardiac output in dogs. American Journal of Veterinary Research Aug; 62(8): 1255-1261

L2.19. Hatfield C, McDonell W, Lemke D, Black W. (2001) Pharmacokinetics and toxic effects of lithium chloride after intravenous administration in conscious horses. American Journal of Veterinary Research Sep; 62(9): 1387-1392

L2.20. Siddall VJ. Gould R. Peruzzi W. (2001) Comparison of clinician assessment of haemodynamic status with actual data obtained through a minimally invasive lithium dilution method. Presented at the 47th Annual International Respiratory Congress San Antonio, Texas

L2.21. Jonas M, Bruce R, Knight J, Kelly F, O'Brien T, Band D. (2001) Comparison of cardiac output measurements using a continuous arterial waveform analysis monitor (PulseCO) with an indicator dilution technique (LiDCO) in patients in intensive care. Presented at the ICCM Sydney, October

L2.22. Mason DJ, O'Grady M, Woods JP, McDonell W (2002) Comparison of a central and a peripheral (cephalic vein) injection site for the measurement of cardiac output using the lithium-dilution cardiac output technique in anesthetized dogs. Can J Vet Res. 66(3): 207–210

L2.23. Corley K, Donaldson L, Furr M. (2002) Comparison of lithium dilution and thermodilution cardiac output measurements in anaesthetised neonatal foals. Equine Vet J 2002 Sept;34 (6) 598-601

L2.24. Jonas M, Tanser S. (2002) Lithium dilution measurement of cardiac output and arterial pulse waveform analysis: an indicator dilution calibrated beat-by-beat system for continuous estimation of cardiac output. Current Opinion in Critical Care; 8 : 257 – 261

L2.25. P.R. Roberts, S. Allen, S. Robinson, S.J. Tanser, M.M. Jonas, J.M. Morgan. (2002) Use of lithium dilution assessment of cardiac output to optimise right/left ventricular activation In Resynchronisation Therapy Presented at: 80th Anniversary British Cardiac Society Annual Scientific Conference Harrogate. Pub. In Heart, May 2002: 87 Supplement II (Abstract 146)

L2.26. Mappes A, Dittrich S, Gruendel M, Huebler M, Hetzer R, Kuppe H. Lithium-based indicator dilution measurement of cardiac output in a 10 year old child after orthotopic heart transplantation. Case Report- Berlin Heart Center. [The use of the LiDCOplus Hemodynamic Monitor is unlicensed in patients of less than 40 kgs / 88Ilbs in weight.]

L2.27. Corley KTT, Donaldson LL, Durando MM, Birks EK. (2003) Cardiac output technologies with special reference to the horse. Journal Vet Intern Med. May-Jun;17(3):262-72

L2.28. Hallowell G, Corley K (2005) Use of lithium dilution and pulse contour analysis cardiac output determination in anestheized horses: a clinical evaluation. Vet Anaes & Analgesia 32, 201-211

L2.29. Lobo S, Oliveira N, Lobo F, Rezende E, Borges B, Cunrath G, Silva J, Ronchi L (2007) Oxygen delivery optimization using lithium indicator dilution and pulse power analysis during major surgery in high-risk patients. Poster Presentation ISICEM, Brussels

L2.30. Durando M, Corley K, Boston R, Birks E. (2008) Cardiac output determination by use of lithium dilution during exercise in horses. American Journal Veterinary Research; 69 : 1054 – 1060

L2.31. Flood S, Bodenham A (2010) Lithium: mimicry, mania and muscle relaxants Continuing Education in Anaesthesia, Critical Care & Pain April 15 2010 doi10.1093/bjaceaccp/mkq008

L2.32 Valverde A, Gianotti G, Rioja E, Hathway A. (2011) Comparison of cardiac output determined by arterial pulse pressure waveform analysis method (Flotrac/Vigileo) versus lithium dilution method in anesthetized dogs. J Veterinary Emergency and Critical Care vol 21:328-334

L2.33 Shih A, Maisenbacher H, Bandt C, Ricco C, Bailey J, Rivera J, Estrada A. (2011) Assessment of cardiac output measurement in dogs by transpulmonary pulse contour analysis. Journal of Veterinary Emergency and Critical Care vol 21 (4):321-327

L2.34 Shih A, Giguere S, Vigani A, Shih R, Thuramalla N, Bandt C. (2011) Determination of cardiac output velocity dilution in normovolemia and hypovolemia in dogs. Veterinary Anaesthesia and Analgesia vol 38(4): 279-285