Home / Education / Clinical Papers / GDFT / GDFT hemodynamic stability in parturient women under spinal epidural

GDFT hemodynamic stability in parturient women under spinal epidural

Patient Population
Cesarean.

LiDCO Monitor
LiDCOrapid.

Trial Design
100 term parturient women scheduled for elective cesarean section randomly allocated to GDFT or a control group.

Outcome Impact
The incidence of hypotension and mean phenylephrine dose administered prior to delivery were significantly higher in the control group than in the GDFT group (P < 0.01).

PURPOSE
To investigate whether goal-directed fluid therapy (GDFT) with the LiDCOrapid system can reduce the incidence of maternal hypotension and improve neonatal outcome.

MATERIALS AND METHODS
100 term parturient women with ASA physical status 1 scheduled for elective Cesarean section at Xuan Wu Hospital of Capital Medical University, Beijing were randomly allocated to control or GDFT group.

RESULTS
Maternal outcome in the control group showed a significantly higher incidence of hypotension prior t delivery in the control group than the GDFT group (62% vs 20%, P < 0.01). Higher does of phenylephrine were administered before delivery (P < 0.01) in the control group.

CONCLUSIONS
LiDCOrapid-guided GDFT may provide benefit to healthy parturient women and their newborns.

Xiao W, Duan Q, Zhao L, Chi X et al. Goal-directed fluid therapy may improve hemodynamic stability in parturient women under combined spinal epidural anesthesia for cesarean section and newborn well-being. J. Obstet. Gynaecol. Res. 2015; 41(10):1547–1555

“LiDCOrapid-guided GDFT can reduce the incidence of maternal hypotension and vasopressor requirement during operation, with a subsequent decrease in the incidence of neonatal adverse events.”